CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver
作者： H. Kuniyasu , Y. Luo , K. Fujii , T. Sasahira , Y. Moriwaka
关键词: Epidermal growth factor receptor 、 Receptor 、 Cancer research 、 Cancer 、 HT29 Cells 、 Apoptosis 、 Cell growth 、 Thiorphan 、 Pathology 、 Metastasis 、 Medicine
摘要: Objective: To examine the role of CD10, a characteristic marker liver metastasis colorectal cancers (CRCs). Design: The effect CD10 and Met-enkephalin (MENK) in CD10-positive -negative human CRC cells was investigated under vitro vivo conditions. Human samples were examined. Main outcome measure: CD10-knockdown HT29 CD10-negative CD10-transfected Colo320 nude mice treated with MENK and/or inhibitor (thiorphan). Intracellular signaling ƒO-opioid receptor (DOR) examined by immunoblotting. Results: inhibited growth, invasion, survival following thiorphan-induced inactivation. Thiorphan suppressed cells. Inoculation induced expression liver. Inhibition hepatic cholesterol-conjugated antisense S-oligodeoxynucleotide increased even when did not express CD10. DOR activation decreased phosphorylation epidermal growth factor extracellular signal-regulated kinase p38-dependent apoptosis. Nitric oxide found to induce Co-treatment thiorphan nitric donor had marked antitumor on Of 68 patients, 19 (28%) showed expression, which dependent extent metastasis. concentration metastasis-positive higher than that normal Conclusion: abrogates degrading it, enhances
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