Rapid PCR-based diagnosis of disseminated histoplasmosis in an AIDS patient.

摘要: Disseminated histoplasmosis is an unusual opportunistic infection in patients with advanced HIV living outside endemic areas. Diagnosis usually made on the basis of isolation Histoplasma capsulatum from clinical specimens or histologic examination. Reported case HIV-infected Columbian individual whom diagnosis was established within 24 h collection adequate bronchoalveolar lavage specimen. The by detection specific fungal DNA and confirmed blood, bone marrow respiratory 10 days later. patient recovered under antifungal treatment remained asymptomatic up to last follow-up visit 6 months polymerase chain reaction assay might be a powerful rapid diagnostic tool for non-European invasive infections should further evaluated.