Epidemiological profile of meningococcal disease in the United States.
作者： Lee H. Harrison
DOI: 10.1086/648963
关键词: Immunology 、 Meningococcal vaccine 、 Medicine 、 Meningococcal disease 、 Serotype 、 Neisseria meningitidis 、 Disease 、 Conjugate vaccine 、 Epidemiology 、 Vaccination 、 Virology
摘要: Neisseria meningitidis is a leading cause of bacterial meningitis and other serious infections worldwide. The epidemiological profile N. highly changeable, with great differences in disease incidence serogroup distribution. Six serogroups (namely A, B, C, W-135, X, Y) are responsible for most cases meningococcal worldwide; the caused by each unique. No vaccine available endemic B strains. Two tetravalent (A/C/Y/ W-135) vaccines licensed United States: purified polysaccharide product polysaccharide-protein conjugate vaccine. recommended all adolescents, although coverage remains low, groups at high risk infection. A comprehensive program to prevent invasive States will require vaccination infants; several infants may become near future. Broadly protective also needed.
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