EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration.

摘要: Abstract Objective Applying graph theory, we investigated how cortical sources small worldness (SW) of resting EEG in eyes-closed/open (EC/EO) differs amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) subjects with respect to normal elderly (Nold). Methods was recorded 30 Nold, aMCI, AD during EC EO. Undirected weighted brain network built evaluate core measures. eLORETA lagged linear connectivity used weight the network. Results In EO condition, is characterized by more SW (higher SW) alpha bands less (lower beta2 gamma bands. has same trend, except for delta theta where shows worldness. a similar trend but fluctuations between EO/EC conditions. Furthermore, both conditions, aMCI architecture presents midway properties Nold. At low frequencies (delta e bands) EC, group network’s while superimposable ones. Conclusions state small-world topological healthy controls, confirming hypothesis that an intermediate step along progression. Significance We proposed application theory reactivity order find marker diagnosis – association other techniques neuroimaging could be sensitive progression MCI or conversion into AD.