The relationship of obesity to the metabolic syndrome.

摘要: Obese patients with the metabolic syndrome generally have a visceral (apple-shaped) fat distribution and are at an increased risk of macrovascular disease, while those peripheral (pear-shaped) obesity tend not to abnormalities less risk. This difference appears be related differing functions (and secretory products) adipose tissue (VAT) subcutaneous (SAT), as well fact that VAT drains directly into liver. Thus, it VAT, but SAT, is associated both hepatic biochemical leading insulin resistance syndrome. Insulin products, such free fatty acids their metabolites, cytokines, tumour necrosis factor alpha (TNF-alpha). These factors may activate components inflammatory pathway nuclear kappa-B (NFkappaB), inhibit signalling. further decreased levels another product, adiponectin. The incidence prevalence increasing unprecedented rate. classic treatment weight loss via lifestyle modification. However, prevention comorbidity can also achieved by modifying mechanisms which causes these comorbid conditions. For instance, now known peroxisome proliferator-activated receptor (PPAR) family transcriptional regulators crucial in regulating development metabolism; this helps explain why compounds PPARgamma agonist activity, e.g. thiazolidinediones, increase action through effects metabolism.