Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways

摘要: The human immunodeficiency virus-1 (HIV-1) infects helper CD4+ T cells, and causes T-cell depletion immunodeficiency. In the past 30 years, significant progress has been made in antiretroviral therapy, disease become manageable. Nevertheless, an effective vaccine is still nowhere sight, a cure or functional awaits discovery. Among possible curative therapies, traditional mostly targeting viral proteins, proven ineffective. It that HIV-dependent host cofactors may offer alternatives, both for preventing HIV transmission forestalling progression. Recently, actin cytoskeleton its regulators blood cells have emerged as major could be targeted. novel concept cortical barrier to entry early post-entry migration led nascent model of virus-host interaction at layer. Deciphering cellular regulatory pathways manifested exciting prospects future therapeutics. this review, we describe study interactions with cytoskeleton. We also examine potential pharmacological targets emerge from interaction. addition, briefly discuss several pathway-based anti-HIV drugs are currently development testing.