Lifestyle intervention might easily improve blood pressure in hypertensive men with the C genotype of angiotensin II type 2 receptor gene

摘要: BACKGROUND/OBJECTIVES: Recent studies have reported an association of the angiotensin II type 2 receptor (AT2R) 3123Cytosine/Adenine (3123C/A) polymorphism with essential hypertension and cardiovascular diseases. The purpose study was to investigate whether AT2R 3123C/A affects blood pressure for free-living hypertensive men during a 5-month intervention period. SUBJECTS/METHODS: subjects were Japanese aged 40 75 years who agreed in period from 2004 2011. Detection determined by polymerase chain reaction. dietary designed decrease salt level increase potassium through cooking instructions self-monitoring diet. exercise session consisted activities such as stretching, resistance training, walking. Blood pressure, urinary sodium excretion, lifestyle data, non-fasting venous sample collected at baseline after RESULTS: Thirty nine eligible participation follow-up rate 97.4%. C allele proportion 57.9%. X-chromosome-linked, therefore we analyzed A genotypes. At baseline, no significant differences observed between genotype groups. After intervention, there habit Nevertheless, estimated excretion (g/day) significantly decreased only (13.0-10.3, P = 0.031). No change systolic (SBP) (mmHg) genotype, but (150.0-141.5, 0.024). CONCLUSTIONS: In it might be easy improve SBP men, however generalization could not achieved small size.