Genetic and Prognostic Differences of Non-small Cell Lung Cancer between Elderly Patients and Younger Counterparts
作者： Kenichi Suda , Kenji Tomizawa , Hiroshi Mizuuchi , Simon Ito , Hirokazu Kitahara
DOI:
关键词: Lung cancer 、 Pathology 、 Multivariate analysis 、 Pathological 、 Lung 、 Histology 、 Stage (cooking) 、 Epidermal growth factor 、 Oncology 、 Anaplastic lymphoma kinase 、 Internal medicine 、 Medicine
摘要: Many elderly patients suffer from lung cancers, but it is not clear if their cancers differ those of younger patients. In this study, we compared genetic and prognostic characteristics aged ≥75 years with ≤ 64 years. the analysis, explored 292 surgically treated non-squamous cell known mutational status epidermal growth factor (EGFR) anaplastic lymphoma kinase (ALK). retrospectively analyzed 405 non-small (NSCLCs) before era routine clinical application post-surgical adjuvant chemotherapy. Postsurgical recurrence-free survival (RFS) was between counterparts. The analysis showed cancer to have higher prevalence EGFR mutations (53.1 % vs 42.0%, P = 0.15) lower ALK translocation (0 4.5%, 0.23) than postsurgical RFS similar NSCLC However in multivariate adjusting for gender, smoking status, pathological stage, histology, had significantly worse prognoses (HR 1.57, 95% CI, 1.08-2.29; 0.02) These results suggest differences aspects
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