Monoclonal antibodies against intermediate cytoskeletal filaments. Their importance in the study of tissue differentiation and biopsy diagnosis

摘要: The expression of intermediate filaments during tissue differentiation, in mature tissues and their neoplastic derivatives (lungs, thyroid gland, kidney, uterus, CNS) was investigated by means monoclonal antibodies prepared our departments (Institute Molecular Genetics, Czechoslovak Academy Sciences, Prague the Department Immunology Biology, Brno). conclusions these investigations provide evidence restricted specificity detection relation to germ layers mesenchymal vs. epithelial set-up need knowledge differential programme a given for interpretation presence tumours which develop from it.