Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection.

摘要: Objective To use multimodality imaging to explore the relationship of biomarkers inflammation, T-cell activation and monocyte with coronary calcification subclinical vascular disease in a population HIV-infected patients on antiretroviral therapy (ART). Design Cross-sectional. Methods A panel soluble cellular inflammation immune was measured 147 adults ART HIV RNA less than 1000 copies/ml low-density lipoprotein cholesterol (LDL-C) 130 mg/dl or less. We examined calcium (CAC) score multiple ultrasound measures disease. Results Overall, median (interquartile range, IQR) age 46 (40-53) years; three-quarters participants were male two-thirds African-American. Median 10-year Framingham risk 6%. Participants CAC more 0 older, likely be African-American had higher current lower nadir CD4 counts. Most similar between those without CAC; however, CD14 independently associated after adjustment for traditional factors. Among zero, systemic correlated carotid intima-media thickness brachial hyperemic velocity, respectively. Compared normal only, increasing degrees levels sCD14, hs-CRP fibrinogen (all P Conclusion Soluble is artery calcification, and, among detectable calcium, predicts extent other beds. Future studies should investigate utility characterize phenotypes this population.