Pain induced by propofol - clinical studies on drug composition and adminstration

摘要: Over the last 25 years a number of new anaesthetic drugs have been introduced on market to allow for better patient satisfaction and faster recovery after anaesthesia sedation. Propofol (2,6-di-isopropylphenol), one our most common iv anaesthetics, is associated with pleasant sleep rapid little postoperative nausea. When used induction propofol causes severe or even intolerable pain discomfort injection in up 90 % patients. Pain ranked by anaesthesiologists as seventh important clinical problem modern anaesthesia. The concentration free within aqueous phase drug formula believed be particularly pain. The general aim these studies was investigate if we could reduce local induced various measures. Traditional long-chain triglyceride (LCT) emulsions were I-III, while medium- (MCT/LCT) III-V. Both formulas compared study III. In I influence carrier fluid evaluated. Simultaneous infusion found not intensity but decrease duration at site injection. In II investigated effect bolus rates injection. There no differences incidence, between slower compared. In III two different administration. based MCT/LCT lower than those LCT only. Study IV designed examine venous occlusion applied during immediately reduces Venous increase injection, indicating that response fades prolonged intravascular exposure. Study V carried out can reduced previous low-dose administration same route. A incidence moderate low dose had administered. Our results show are less traditional formulas. Furthermore propofol-induced route. These measures easily taken any anaesthetist virtually situation calling anaesthesia.