Microscopic determination of the phase diagrams of lysozyme and γ-crystallin solutions

摘要: We determine the phase diagrams of two widely studied protein solutions, namely, lysozyme and γ-crystallin in water added salt, within a short-range, pair-potential representation macroparticle interactions. A one-parameter fit model is performed on basis static or dynamic light scattering self-interaction chromatography data. Demixing crystallization curves, as calculated through numerical approaches, turn out to be good agreement with experimental protein-rich−protein-poor solubility envelopes. Our findings highlight minimal assumptions about nature microscopic potential allowing satisfactory reproduction phase-diagram topology globular solutions.