Nimodipine After Resuscitation From Out-of-Hospital Ventricular Fibrillation

摘要: One hundred fifty-five consecutive patients resuscitated after out-of-hospital ventricular fibrillation by a physician-manned advanced life support unit were randomly assigned to receive nimodipine or placebo at dosage of 10 μg/kg as an intravenous injection immediately restoration spontaneous circulation, followed infusion 0.5 per minute for 24 hours. No significant difference was found in the 1-year survival rate nimodipine-treated (30 [40%] 75 patients) and placebo-treated (29 [36%] 80 patients). Recurrent during treatment occurred one patient group compared with 12 group. In post hoc analysis very long delays (more than minutes), higher (eight [47%] 17 (two [8%] 26 Nimodipine may be benefit delayed resuscitation. (JAMA. 1990;264:3171-3177)