Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis
作者： Hao Shi , Ya Li , Xiaozhong Wang , Cheng Lu , Lilan Yang
DOI: 10.1371/JOURNAL.PONE.0076787
关键词: Publication bias 、 Meta-analysis 、 Pathogenesis 、 Methylation 、 Oncology 、 Biology 、 Odds ratio 、 Ovarian cancer 、 DNA methylation 、 Internal medicine 、 Bioinformatics 、 Cancer
摘要: Background The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation RASSF1A critical to pathogenesis cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in progression ovarian A number studies have discussed between promoter and However, they were mostly based on a small samples showed inconsist results, Therefore, we conducted meta-analysis better identify association. Methods Eligible identified by searching PubMed, EMBASE, Web Science, CNKI databases using systematic strategy. We pooled odds ratio (ORs) from individual fixed-effects model. performed heterogeneity publication bias analysis simultaneously. Results Thirteen studies, with 763 cancer patients 438 controls included meta-analysis. The frequencies ranged 30% 58% (median 48%) group 0 21% 0) control group. significantly higher than those 11.17 (95% CI = 7.51–16.61) versus corresponding under model. Conclusion results suggested that had strong
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