Regulation of the uncoupling protein gene expression.

摘要: Uncoupling protein (UCP) is essential to the thermogenic function of brown adipose tissue (BAT). The role this due its capacity uncouple oxidative phosphorylation in a regulated manner. potential BAT determined by content UCP. gene encoding under complex regulation. Catecholamines, via cAMP, thyroid hormone and retinoic acid, directly stimulate acting upon an upstream (-2.28/-2.49 kb) enhancer sequence, but cAMP may act other sequences as well. CCAAT binding proteins peroxisome proliferation activator receptor (PPAR) gamma 2 have also been implicated regulation on discrete sequences. While response acid elements (TRE RARE) well defined, (CRE) remain elusive. two TREs are 27 bp apart between -2.33 kb -2.39 kb. synergism seems reside 39 sequence downstream (-2.28/-2.32 kb). most important CRE, RARE, cell-specific putative PPAR element all concentrated 90 regulatory great complexity (-2.40/-2.49 Other hormones, such insulin glucocorticoids, IGF-I modulate expression their effects seem be largely indirect. Understanding UCP facilitate development interventions obesity related disorders.