Noncoding RNAs, post-transcriptional RNA operons and Chinese hamster ovary cells
作者： Fabian Stiefel , Simon Fischer , Matthias Hackl , René Handrick , Friedemann Hesse
DOI: 10.4155/PBP.14.65
关键词: Chinese hamster ovary cell 、 RNA 、 Piwi-interacting RNA 、 microRNA 、 Non-coding RNA 、 Biology 、 Chinese hamster 、 Operon 、 Context (language use) 、 Genetics 、 Computational biology
摘要: Chinese hamster ovary cells are among the biotechnologically most relevant production systems for biopharmaceuticals. With availability of genomic sequences hamster, rational biotechnology-driven approaches to optimize this cell factory have become available. Here, we review current status noncoding RNAs as members post-transcriptional operon concept in context line engineering and bioprocessing. In addition, suggest that they already now keep their promises tools increasing specific productivity thus time space yield biopharmaceutical production, a feature will allow more cost efficient processes future.
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