Valproate prophylaxis in a prospective clinical trial of refractory bipolar disorder.

摘要: Objective The authors studied the efficacy of valproate plus lithium and triple therapy with lithium, carbamazepine, in refractory bipolar illness. Method subjects were 24 outpatients who had completed an intended 3-year crossover study comparing their combination. Patients entered a 1-year phase because inadequate response or major side effects, patients responses offered additional year treatment all three mood-stabilizing drugs. Results Six (33%) 18 evaluable moderate to marked lithium; four these six not responded any previous condition. Three seven therapy, although only one was marked. Conclusions Some disorder carbamazepine received clinically relevant prophylactic benefit from when used therapy.