In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India.
作者： S Ravikumar , G Ramanathan , M Gnanadesigan , A Ramu , V Vijayakumar
DOI: 10.1016/S1995-7645(11)60209-5
关键词: Plasmodium falciparum 、 In vitro 、 Traditional medicine 、 Phenols 、 Seaweed extract 、 West coast 、 Chaetomorpha antennina 、 Artemether 、 Phytochemical 、 Biology
摘要: Objective To identify the in vitro antiplasmodial activity of seaweed plants against Plasmodium falciparum strains. Methods A total eight seaweeds were collected from Kanyakumari district, Tamilnadu, India. The was performed 96 well plates , and preliminary phytochemcial analysis for extracts. Results Of selected Enteromorpha intestinalis (2.61%) showed maximum percentage extraction. minimum concentration inhibitory (IC 50 ) value observed with Chaetomorpha antennina [(26.37±4.14) μg/mL] further, positive controls such as chloroquine artemether activities (19.10±5.93) (6.03±0.21) μg/mL concentrations, respectively. phytochemical extracts a variety constituents carboxylic acids, phenols, protein, resins, steroids sugars. Conclusions extract might due to presence sugars phenolic compounds. From present findings, it is concluded that, can be further used putative drugs near future.
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sci-hub.se 参考文章(22)
Babita Aggarwal, Mohd. Ali, Vijender Singh, Rajeev K. Singla, Isolation and characterization of phytoconstituents from the stems of Ichnocarpus frutescens. Chinese Journal of Natural Medicines. ,vol. 8, pp. 401- 404 ,(2010) , 10.1016/S1875-5364(11)60001-0
W.M. Bandaranayake, Traditional and medicinal uses of mangroves Mangroves and Salt Marshes. ,vol. 2, pp. 133- 148 ,(1998) , 10.1023/A:1009988607044
William Kemp, Qualitative Organic Analysis: Spectrochemical Techniques ,(1986)
Paul W. Sherman, Jennifer Billing, Darwinian Gastronomy: Why We Use Spices BioScience. ,vol. 49, pp. 453- 463 ,(1999) , 10.2307/1313553
P.J. Waako, B. Gumede, P. Smith, P.I. Folb, The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. Journal of Ethnopharmacology. ,vol. 99, pp. 137- 143 ,(2005) , 10.1016/J.JEP.2005.02.017
A. C. Stierle, J. H. Cardellina, F. L. Singleton, A marine Micrococcus produces metabolites ascribed to the sponge Tedania ignis. Cellular and Molecular Life Sciences. ,vol. 44, pp. 1021- 1021 ,(1988) , 10.1007/BF01939910
A. Rowe, A.R. Berendt, K. Marsh, C.I. Newbold, Plasmodium falciparum : a family of sulphated glycoconjugates disrupts erythrocyte rosettes Experimental Parasitology. ,vol. 79, pp. 506- 516 ,(1994) , 10.1006/EXPR.1994.1111
N. Azas, N. Laurencin, F. Delmas, C. Di Giorgio, M. Gasquet, M Laget, P. Timon-David, Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitology Research. ,vol. 88, pp. 165- 171 ,(2002) , 10.1007/S004360100454
Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi, Malaiyandi Venkatesan, Andy Ramu, Mangrove plants as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India Parasitology Research. ,vol. 108, pp. 1405- 1410 ,(2011) , 10.1007/S00436-010-2184-4
Philippe Rasoanaivo, Suzanne Ratsimamanga-Urverg, David Ramanitrahasimbola, Herintsoa Rafatro, Albert Rakoto-Ratsimamanga, Criblage d’extraits de plantes de Madagascar pour recherche d’activité antipaludique et d’effet potentialisateur de la chloroquine Journal of Ethnopharmacology. ,vol. 64, pp. 117- 126 ,(1999) , 10.1016/S0378-8741(98)00114-7