Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy

摘要: BACKGROUND: Persistent chromosome segregation errors represent a conspicuous feature of human neoplasms. It is widely accepted that this chromosomal instability associated with poor prognosis; however, its effect on therapeutic response matter conjecture. METHODS: Here, the role in patients rectal adenocarcinoma to chemoradiation therapy (CRT) was examined. Pretreatment samples from 62 were surveyed for evidence mis-segregation and frequency correlated pathological CRT as determined by tumor regression grade after surgical resection irradiated tumors. RESULTS: Surprisingly, it found predicted enhanced (odds ratio, 3.9; P 5.02). Furthermore, inversely cells exhibited during anaphase (correlation coefficient, 0.94; <.05). Strikingly, elevated combined decreased levels DNA damage repair protein Mre11 portended markedly 54.0; 5.008). CONCLUSIONS: The results current study demonstrate favorable predictor locally invasive adenocarcinoma. Therefore, authors propose downstream structural chromosomes resulting potentiates DNA-damaging therapies synergizes deficiencies machinery. This work identifies novel mechanistic marker foretells treatment suggests concomitant targeting whole-chromosome may constitute an effective strategy. Cancer 2014;120:1733–42. V C 2014 American Society.