Remote Central-to-Axial Chirality Conversion: Direct Atroposelective Ester to Biaryl Transformation.
作者： Achim Link , Christof Sparr
关键词: Atropisomer 、 Reagent 、 Combinatorial chemistry 、 Chemistry 、 Aryl 、 Chirality (chemistry) 、 Stereoselectivity 、 Axial chirality 、 Stereocenter 、 Silanes
摘要: A strategy for the remote central-to-axial chirality conversion by simultaneous planarization of an encoding and a transient stereocenter is presented. Based on diastereoselective double addition chiral 1,5-bifunctional organomagnesium alkoxide reagent to broad range aryl ester substrates, axially biaryls are directly obtained upon in situ reduction. Various structurally distinct atropisomeric biaryl silanes that serve as valuable anion surrogates accessible one step with e.r. values up 98:2.
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