Massive antenatal fetomaternal hemorrhage: evidence for long-term survival of fetal red blood cells.

作者: Morten H. Dziegiel , Ole Koldkjaer , Adela Berkowicz

DOI: 10.1111/J.0041-1132.2005.04262.X

关键词: Blood cellObstetricsAnemiaPreeclampsiaWhole bloodRed blood cellPregnancyPediatricsFetusObstetrics and gynaecologyMedicine

摘要: BACKGROUND: Massive fetomaternal hemorrhage (FMH) can lead to life-threatening anemia. Quantification based on flow cytometry with anti-hemoglobin F (HbF) is applicable in all cases but underestimation of large fetal bleeds has been reported. A FMH from an ABO-compatible fetus allows estimation the life span red blood cells (RBCs) maternal circulation. CASE REPORT: The mother went obstetrician twice antepartum owing symptoms assumed be preeclampsia; that, however, was not found. She later delivered by cesarean section diminished movements. No weight gain observed during last 2 weeks pregnancy. STUDY DESIGN AND METHODS: Fetal RBCs were quantified anti-HbF, anti-Fya, anti-s, and anti-Jkb a regular basis. RESULTS: infant had anemia at delivery determined 314 ± 17 mL (± SD) whole blood. It that two antenatal visits associated FMH. Postpartum follow-up showed circulation detectable anti-HbF up 119 days. agreement quantification anti-Jkb, although they less sensitive. CONCLUSION: close adult RBCs.

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