Extensive allelic variation and ultrashort telomeres in senescent human cells
作者： Duncan M. Baird , Jan Rowson , David Wynford-Thomas , David Kipling
DOI: 10.1038/NG1084
关键词: Senescence 、 Cell aging 、 DNA replication 、 Telomerase 、 Biology 、 Cell division 、 Telomere 、 Genetics 、 Allele 、 Mutation
摘要: … Quantitative fluorescence in situ hybrization (Q-FISH) measures fluorescence arising from the hybridization of (TTAGGG) n in situ to metaphase chromosomes 9 . Although this permits …
nature.com
sci-hub.se 参考文章(29)
Fiona S. Wyllie, Christopher J. Jones, Julia W. Skinner, Michele F. Haughton, Corrin Wallis, David Wynford-Thomas, Richard G.A. Faragher, David Kipling, Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts Nature Genetics. ,vol. 24, pp. 16- 17 ,(2000) , 10.1038/71630
D. M. Baird, A. J. Jeffreys, N. J. Royle, Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. The EMBO Journal. ,vol. 14, pp. 5433- 5443 ,(1995) , 10.1002/J.1460-2075.1995.TB00227.X
C.M. Counter, A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley, S. Bacchetti, Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. The EMBO Journal. ,vol. 11, pp. 1921- 1929 ,(1992) , 10.1002/J.1460-2075.1992.TB05245.X
T. T. Perls, J. Wilmoth, R. Levenson, M. Drinkwater, M. Cohen, H. Bogan, E. Joyce, S. Brewster, L. Kunkel, A. Puca, Life-long sustained mortality advantage of siblings of centenarians Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 8442- 8447 ,(2002) , 10.1073/PNAS.122587599
J. M. J. M. Zijlmans, U. M. Martens, S. S. S. Poon, A. K. Raap, H. J. Tanke, R. K. Ward, P. M. Lansdorp, Telomeres in the mouse have large inter-chromosomal variations in the number of t2ag3 repeats Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 7423- 7428 ,(1997) , 10.1073/PNAS.94.14.7423
Helen Varley, Hilda A. Pickett, Jennifer L. Foxon, Roger R. Reddel, Nicola J. Royle, Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genetics. ,vol. 30, pp. 301- 305 ,(2002) , 10.1038/NG834
Calvin B. Harley, A. Bruce Futcher, Carol W. Greider, Telomeres shorten during ageing of human fibroblasts. Nature. ,vol. 345, pp. 458- 460 ,(1990) , 10.1038/345458A0
David Kipling, Howard J. Cooke, Hypervariable ultra-long telomeres in mice. Nature. ,vol. 347, pp. 400- 402 ,(1990) , 10.1038/347400A0
R. C. Allsopp, H. Vaziri, C. Patterson, S. Goldstein, E. V. Younglai, A. B. Futcher, C. W. Greider, C. B. Harley, Telomere length predicts replicative capacity of human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 10114- 10118 ,(1992) , 10.1073/PNAS.89.21.10114
Zheng Tan, Telomere shortening and the population size-dependency of life span of human cell culture: further implication for two proliferation-restricting telomeres. Experimental Gerontology. ,vol. 34, pp. 831- 842 ,(1999) , 10.1016/S0531-5565(99)00056-X