Origin of ciliated alveolar epithelial cells in bleomycin-induced lung injury.

摘要: Bleomycin is known to induce diffuse pulmonary fibrosis and epithelial metaplasia. The reaction of the alveolar epithelium following a single intravenous or multiple intraperitoneal injections bleomycin mice now examined in combined morphologic cytodynamic study. Necrosis Type 1 cells was observed, followed by proliferation 2 cells, common reparative process. proliferated transformed variety forms, including ciliated with features intermediate between bronchiolar epithelium. No evidence cell injury increased division found bronchial It concluded that metaplastic are produced an abnormal process results suggest that, whereas "resting" not vulnerable bleomycin, postmitotic phase drug may modify synthetic mechanisms cellular differentiation thereby