HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis
作者： Christian Paul , Ulrich Schoenwald , Hans Truckenbrodt , MariaP. Bettinotti , G�nter Br�nnler
DOI: 10.1007/BF00222468
关键词: Polymerase chain reaction 、 Genetics 、 Haplotype 、 Allele 、 Biology 、 Arthritis 、 Immunology 、 Exon 、 Linkage disequilibrium 、 HLA-DP 、 Gene
摘要: We investigated the polymorphic second exon of HLA-DPB1 and HLA-DRB1 genes, using in vitro DNA amplification by polymerase chain reaction (PCR) oligonucleotide hybridization 136 patients with early onset pauciarticular juvenile chronic arthritis (EOPA-JCA) 199 healthy controls. The analysis system revealed that most DRB1 alleles are not indifferent respect to susceptibility EOPA-JCA. There is a hierarchy susceptible (DRB1*08, DR5), "permissive" (DRB1*01), moderately "protective" (DR2, DRB1*04), (DRB1*07) alleles. In contrast, no could be shown for system. DPB1*0201 was found susceptible. relatively frequent DPB1*0402 DPB1*0401 seem indifferent. associations DPB1*0201, DR5, DRB1*08 independent each other: say they, brought about linkage disequilibrium. DR5 show evidence interaction pathogenesis Interaction seems likely between DRB1*08, or DR6 DRB1*08. strongest exists common DQ factor associated both Finally, we observed among various marker combinations, where risk developing EOPA-JCA increases number markers present an individual.
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X Gao, M Fernandez-Vina, W Shumway, P Stastny, 4.3-06 DNA typing for class II HLA antigens with allele-specific or group-specific amplification. Typing for subsets of HLA-DR4 Human Immunology. ,vol. 26, pp. 30- ,(1989) , 10.1016/0198-8859(89)90650-2
Nials Morling, Johannes Friis, Lars Fugger, Jergen Geergsen, Carsten Heilmann, Freddy Karup Pedersen, Niels Bdum, Arne Svejgaard, DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis. Tissue Antigens. ,vol. 38, pp. 16- 23 ,(1991) , 10.1111/J.1399-0039.1991.TB02030.X
Niels ØDum, Niels Morling, Johannes Friis, Carsten Heilmann, Jens J. Hyldig-Nielsen, Bodil K. Jakobsen, Freddy Karup Pedersen, Per Platz, Lars P. Ryder, Arne Svejgaard, Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. Tissue Antigens. ,vol. 28, pp. 245- 250 ,(2008) , 10.1111/J.1399-0039.1986.TB00490.X
Arne Svejgaard, Per Plartz, Lars P. Ryder, HLA and disease 1982--a survey Immunological Reviews. ,vol. 70, pp. 193- 218 ,(1983) , 10.1111/J.1600-065X.1983.TB00715.X
Catherine Van Kerckhove, Lorie Luyrink, Maruja S. Elma, Walter P. Maksymowych, Joseph E. Levinson, Martin G. Larson, Edmund Choi, David N. Glass, HLA-DP/DR interaction in children with juvenile rheumatoid arthritis. Immunogenetics. ,vol. 32, pp. 364- 368 ,(1990) , 10.1007/BF00211652
Xiaojiang Gao, Marcelo Fernandez-Vina, Wayne Shumway, Peter Stastny, DNA typing for class II HLA antigens with allele-specific or group-specific amplification. III, Typing for 24 alleles of HLA-DP Human Immunology. ,vol. 27, pp. 40- 50 ,(1991) , 10.1016/0198-8859(90)90094-6
Catherine Van Kerckhove, Hector Melin-Aldana, Maruja S. Elma, Lorie Luyrink, Patricia Donnelly, Janalee Taylor, Walter P. Maksymowych, Daniel J. Lovell, Edmund Choi, David N. Glass, A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis Immunogenetics. ,vol. 32, pp. 304- 308 ,(1990) , 10.1007/BF00211643
C. Nevinny-Stickel, M.d.l.P. Bettinotti, A. Andreas, M. Hinzpeter, K. Mühlegger, G. Schmitz, E.D. Albert, Nonradioactive HLA class II typing using polymerase chain reaction and digoxigenin-11-2′-3′-dideoxyuridinetriphosphate-labeled oligonucleotide probes Human Immunology. ,vol. 31, pp. 7- 13 ,(1991) , 10.1016/0198-8859(91)90042-8
F. Sinigaglia, M. Guttinger, J. Kilgus, D. M. Doran, H. Matile, H. Etlinger, A. Trzeciak, D. Gillessen, J. R. L. Pink, A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. Nature. ,vol. 336, pp. 778- 780 ,(1988) , 10.1038/336778A0
Andrea J. Sant, Ronald N. Germain, Intracellular competition for component chains determines class II MHC cell surface phenotype. Cell. ,vol. 57, pp. 797- 805 ,(1989) , 10.1016/0092-8674(89)90794-0