Metformin: Metabolic Rewiring Faces Tumor Heterogeneity

摘要: Tumor heterogeneity impinges on all the aspects of tumor history, from onset to metastasis and relapse. It is growingly recognized as a propelling force for adaptation environmental micro-environmental cues. Metabolic perfectly falls into this process. strongly contributes metabolic plasticity which characterizes cancer cell subpopulations-capable adaptive switching under stress conditions, between aerobic glycolysis oxidative phosphorylation-in both convergent divergent modality. The mitochondria appear at center-stage in process thus, targeting may prove therapeutic value. Metformin oldest most used anti-diabetic medication its relationship with has witnessed rises last 30 years. We believe it useful revisit main mechanisms action metformin light emerging views heterogeneity. first analyze consolidated view mitochondrial mechanism then we frame latter context strategies, stem selection, zonation tumors microenvironment. This provide more critical point and, some extent, help shed controversial evidence metformin's anticancer action.