Lack of association between debrisoquine 4-hydroxylase (CYP2D6) gene polymorphisms and schizophrenia.
作者： E. G. Jönsson , M-L. Dahl , H-K. Roh , M. Jerling , G. C. Sedvall
DOI: 10.1097/00041444-199800810-00004
关键词: Endocrinology 、 Internal medicine 、 Dopamine transporter 、 CYP2D6 、 Medicine 、 Debrisoquine 、 Metabolism 、 Cytochrome p450 enzyme 、 Schizophrenia 、 CYP2D6 Gene
摘要: Debrisoquine 4-hydroxylase (CYP2D6) is a cytochrome P450 enzyme involved in the metabolism of most neuroleptics, which are drugs choice for treatment psychotic symptoms. CYP2D6 brain was suggested to be functionally similar dopamine transporter, thus possibly influencing
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