Distribution of Animal Drugs between Skim Milk and Milk Fat Fractions in Spiked Whole Milk: Understanding the Potential Impact on Commercial Milk Products.
作者： Heldur Hakk , Nancy W. Shappell , Sara J. Lupton , Weilin L. Shelver , Wendy Fanaselle
关键词: Oxytetracycline 、 Chemistry 、 Drug 、 Lipophilicity 、 Partition coefficient 、 Sulfadimethoxine 、 Ketoprofen 、 Food science 、 Skimmed milk 、 Distribution (pharmacology)
摘要: Seven animal drugs [penicillin G (PENG), sulfadimethoxine (SDMX), oxytetracycline (OTET), erythromycin (ERY), ketoprofen (KETO), thiabendazole (THIA), and ivermectin (IVR)] were used to evaluate the drug distribution between milk fat skim fractions of cow milk. More than 90% radioactivity was distributed into fraction for ERY, KETO, OTET, PENG, SDMX, approximately 80% THIA, 13% IVR. The significantly correlated drug's lipophilicity (partition coefficient, log P, or D, which includes ionization). Data fit with linear mixed effects models; best obtained within this data set D versus observed ratios. These candidate empirical models serve assisting predict concentration these in a variety products.
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