Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.

作者: B. P. Fairfax , P. Humburg , S. Makino , V. Naranbhai , D. Wong

DOI: 10.1126/SCIENCE.1246949

关键词: Genome-wide association studyInterferon Regulatory Factor 2Major histocompatibility complexBiologyRegulation of gene expressionIRF8Innate immune systemGeneticsExpression quantitative trait lociInterferon regulatory factors

摘要: Introduction Many genetic variants associated with common disease susceptibility occur close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …

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