Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

作者: Regis R Lamberts , Shivanjali J Lingam , Heng-Yu Wang , Ilse AE Bollen , Gillian Hughes

DOI: 10.1186/1475-2840-13-72

关键词: Ejection fractionDiabetes mellitusStroke volumeDiastoleMyocardial fibrosisVasodilationMedicineType 2 diabetesInternal medicineFibrosisCardiologyEndocrinology

摘要: Background Diastolic dysfunction is a key factor in the development and pathology of cardiac diabetes, however exact underlying mechanism remains unknown, especially humans. We aimed to measure contraction, relaxation, expression calcium-handling proteins fibrosis myocardium diabetic patients with preserved systolic function.

参考文章(60)
Aaron M. From, Christopher G. Scott, Horng H. Chen, The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study. Journal of the American College of Cardiology. ,vol. 55, pp. 300- 305 ,(2010) , 10.1016/J.JACC.2009.12.003
Michael R. Zile, William H. Gaasch, Abnormal Calcium Homeostasis Journal of the American College of Cardiology. ,vol. 58, pp. 155- 157 ,(2011) , 10.1016/J.JACC.2010.10.068
Abdel-Rauf Zeina, Majed Odeh, Uri Rosenschein, Ghassan Zaid, Elisha Barmeir, Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography angiography. Coronary Artery Disease. ,vol. 19, pp. 37- 41 ,(2008) , 10.1097/MCA.0B013E3282F2F19E
S E Litwin, T E Raya, P G Anderson, S Daugherty, S Goldman, Abnormal cardiac function in the streptozotocin-diabetic rat. Changes in active and passive properties of the left ventricle. Journal of Clinical Investigation. ,vol. 86, pp. 481- 488 ,(1990) , 10.1172/JCI114734
Peter Boknik, Larry R. Jones, Uwe Kirchhefer, Jörg Knapp, Bettina Linck, Hartmut Lüss, Andreas Meissner, Frank U. Müller, Wilhelm Schmitz, Ute Vahlensieck, Joachim Neumann, Iva Lüss, Expression of Cardiac Calcium Regulatory Proteins in Atrium v Ventricle in Different Species Journal of Molecular and Cellular Cardiology. ,vol. 31, pp. 1299- 1314 ,(1999) , 10.1006/JMCC.1999.0962
Hannes Reuter, Sabine Grönke, Christian Adam, Maida Ribati, Jan Brabender, Carsten Zobel, Konrad F. Frank, Jens Wippermann, Robert H. G. Schwinger, Klara Brixius, Jochen Müller-Ehmsen, Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients. Molecular and Cellular Biochemistry. ,vol. 308, pp. 141- 149 ,(2008) , 10.1007/S11010-007-9622-3
Sahika Guner, Ebru Arioglu, Aydin Tay, Atalay Tasdelen, Sait Aslamaci, Keshore R. Bidasee, U. Deniz Dincer, Diabetes decreases mRNA levels of calcium-release channels in human atrial appendage Molecular and Cellular Biochemistry. ,vol. 263, pp. 143- 150 ,(2004) , 10.1023/B:MCBI.0000041856.92497.0C
Martina Krüger, Kamila Babicz, Marion von Frieling-Salewsky, Wolfgang A. Linke, Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy. Journal of Molecular and Cellular Cardiology. ,vol. 48, pp. 910- 916 ,(2010) , 10.1016/J.YJMCC.2010.02.012
T J Regan, C F Wu, C K Yeh, H A Oldewurtel, B Haider, Myocardial composition and function in diabetes. The effects of chronic insulin use. Circulation Research. ,vol. 49, pp. 1268- 1277 ,(1981) , 10.1161/01.RES.49.6.1268