A norepinephrine coated magnetic molecularly imprinted polymer for simultaneous multiple chiral recognition

摘要: A newly designed molecularly imprinted polymer (MIP) material was developed and successfully used as recognition element for enantioselective by microchip electrophoresis. In this work, polymers were facilely prepared employing Fe3O4 nanoparticles (NPs) the supporting substrate norepinephrine functional monomer in presence of template molecule a weak alkaline solution. After extracting embedded molecules, produced Fe3O4@polynorepinephrine (MIP–Fe3O4@PNE) NPs have cavities complementary to three dimensional shape molecules favoring high binding capacity magnetism property easy manipulation. The MIP–Fe3O4@PNE with l-tryptophan, l-valine, l-threonine, Gly-l-Phe, S-(−)-ofloxacin or S-(−)-binaphthol packed polydimethylsiloxane microchannel via magnetic field novel stationary phase successful enantioseparation corresponding target analysts. NPs-based electrophoresis system exhibited strong ability, excellent high-performance, admirable reproducibility stability, which provided powerful protocol separation enantiomers within short analytical time opened up an avenue multiplex chiral compound assay various systems.