Synthesis of perfluoroaliphatic grignard reagents
作者： D.D. Denson , C.F. Smith , C. Tamborski
DOI: 10.1016/S0022-1139(00)82624-X
关键词: Solvent 、 Diethyl ether 、 Organic chemistry 、 Reagent 、 Chemistry 、 Cyclohexanone 、 Stoichiometry 、 Medicinal chemistry 、 Tetrahydrofuran 、 Halide 、 Yield (chemistry)
摘要: Abstract Perfluoraliphatic mono- and di-Grignard reagents (R f MgX, XMgR′ MgX) have been conveniently synthesized in excellent yields (90–100%) through metalhalogen exchange reactions. The degree of has found to be subject a number experimental parameters, e.g. the nature solvent (tetrahydrofuran vis-a-vis diethyl ether), type halide displaced, organomagnesium reagent stoichiometry. These sufficient thermal stability at low temperatures (−70°) useful as intermediates for synthesis variety compounds. Various perfluoroaliphatic Grignard reacted with H 3 O + , CO 2 (CF ) cyclohexanone yield R H, OH 1-cyclo-C 6 10 (OH)R compounds, respectively. selection proper reaction conditions, i.e. solvent, temperature time, extremely important preparation derivatives various reagents.
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