Temporo-parietal junction stimulation in the treatment of depersonalization disorder

作者: Antonio Mantovani , Daphne Simeon , Nina Urban , Peter Bulow , Anouk Allart

DOI: 10.1016/J.PSYCHRES.2010.08.022

关键词: Psychiatric status rating scalesAudiologySurgeryDepersonalizationTemporal lobeTranscranial magnetic stimulationParietal lobePsychologyDepersonalization DisorderStimulationDeep brain stimulation

摘要: This is the first clinical trial of repetitive Transcranial Magnetic Stimulation (rTMS) in depersonalization disorder (DPD). After 3 weeks right temporo-parietal junction (TPJ) rTMS, 6/12 patients responded. Five responders received more TPJ rTMS showing 68% DPD symptoms improvement. Right was safe and effective.

参考文章(10)
Helen S. Mayberg, Positron emission tomography imaging in depression: a neural systems perspective Neuroimaging Clinics of North America. ,vol. 13, pp. 805- 815 ,(2003) , 10.1016/S1052-5149(03)00104-7
Mary L. Phillips, Mauricio Sierra, Depersonalization disorder: a functional neuroanatomical perspective Stress. ,vol. 6, pp. 157- 165 ,(2003) , 10.1080/1025389031000138538
Mauricio Sierra, Depersonalization disorder: pharmacological approaches. Expert Review of Neurotherapeutics. ,vol. 8, pp. 19- 26 ,(2008) , 10.1586/14737175.8.1.19
Mauricio Sierra, German E. Berrios, The Cambridge Depersonalisation Scale: a new instrument for the measurement of depersonalisation Psychiatry Research. ,vol. 93, pp. 153- 164 ,(2000) , 10.1016/S0165-1781(00)00100-1
Olaf Blanke, Christine Mohr, Christoph M Michel, Alvaro Pascual-Leone, Peter Brugger, Margitta Seeck, Theodor Landis, Gregor Thut, Linking Out-of-Body Experience and Self Processing to Mental Own-Body Imagery at the Temporoparietal Junction The Journal of Neuroscience. ,vol. 25, pp. 550- 557 ,(2005) , 10.1523/JNEUROSCI.2612-04.2005
Dennis J. L. G. Schutter, D. Martin Laman, Jack van Honk, Anton C. Vergouwen, G. Frank Koerselman, Partial clinical response to 2 weeks of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression The International Journal of Neuropsychopharmacology. ,vol. 12, pp. 643- 650 ,(2009) , 10.1017/S1461145708009553
Daphne Simeon, Orna Guralnik, Erin A. Hazlett, Jacqueline Spiegel-Cohen, Eric Hollander, Monte S. Buchsbaum, Feeling unreal: a PET study of depersonalization disorder. American Journal of Psychiatry. ,vol. 157, pp. 1782- 1788 ,(2000) , 10.1176/APPI.AJP.157.11.1782
Daphne Simeon, Orna Guralnik, James Schmeidler, Margaret Knutelska, Fluoxetine therapy in depersonalisation disorder: randomised controlled trial British Journal of Psychiatry. ,vol. 185, pp. 31- 36 ,(2004) , 10.1192/BJP.185.1.31
Alejandro M. Jiménez-Genchi, Repetitive transcranial magnetic stimulation improves depersonalization: a case report. Cns Spectrums. ,vol. 9, pp. 375- 376 ,(2004) , 10.1017/S1092852900009366
Olaf Blanke, Stphanie Ortigue, Theodor Landis, Margitta Seeck, Stimulating illusory own-body perceptions Nature. ,vol. 419, pp. 269- 270 ,(2002) , 10.1038/419269A