Neurospheroid array on a flexible substrate for cortical microstimulation
作者： Keisuke Okita , Midori Kato-Negishi , Hiroaki Onoe , Shoji Takeuchi
DOI: 10.1109/MEMSYS.2013.6474217
关键词: Materials science 、 Cellular biophysics 、 Microstimulation 、 Multielectrode array 、 Biomedical engineering 、 Spheroid 、 Substrate (printing)
摘要: This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with neuronal spheroid (neurospheroid) array. The MEA has number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that successfully activated neurons within neurospheroid on the microelectrode In addition, was used activate 2D culture cortical cells through neurospheroids. These results mark an important step toward achieving minimally-invasive microstimulation via neurospheroid-based stimulating systems.
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