HPLC-fluorescence assay for measuring mosapride in small volumes of rat plasma
作者： Ching-Ling Cheng , Ya-Win Chang , Chen-Hsi Chou
DOI: 10.1002/BMC.1285
关键词: Analytical chemistry 、 Potassium 、 Chromatography 、 Calibration curve 、 Acetonitrile 、 Chemistry 、 Fluorescence 、 Cisapride 、 Standard solution 、 Mosapride 、 Pharmacokinetics
摘要: A simple and sensitive HPLC-fluorescence assay was developed for the determination of a gastroprokinetic agent mosapride in small volumes rat plasma. Samples (50 μL) were treated with 200 μL internal standard solution (cisapride, 0.1 μg/mL acetonitrile). Chromatographic separation achieved on C18 column by gradient elution mobile phase acetonitrile-water containing 20 mM potassium dihydrogen phosphate, at flow rate 1 mL/min. Fluorescence measured excitation emission set 315 354 nm, respectively. The retention time about 16 min cisapride mosapride. No endogenous substances found to interfere. calibration curve linear from 0.015 10 μg/mL. lower limit quantification intra- inter-day precision expressed as relative deviation did not exceed 7.7%, accuracy within 4.7% nominal concentration. method used successfully investigate disposition kinetics rats. Copyright © 2009 John Wiley & Sons, Ltd.
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