作者: Jason W. Brown
DOI: 10.1016/0006-8993(67)90215-6
关键词: Alzheimer's disease 、 Phylogenesis 、 Neuroscience 、 Biology 、 Cholinergic 、 Nerve growth factor 、 Cholinergic neuron 、 Basal forebrain 、 Degenerative disease 、 Central nervous system 、 Internal medicine 、 Endocrinology
摘要: Nerve growth factor (NGF) receptor mRNA was found to be widely distributed throughout the human central nervous system, with highest levels in basal forebrain; this suggests that NGF may function as a retrograde trophic messenger for forebrain magnocellular cholinergic nerve cells. The degeneration of latter constitutes one main features Alzheimer's disease and it responsible some cognitive impairment characterizes