Is Dextromethorphan a Concern for Causing a False Positive During Urine Drug Screening

摘要: The initial screening for drugs of abuse invariably poses the risk false positives due to cross-reactivity. over-the-counter antitussive medication dextromethorphan (DXM) can cause false-positive results phencyclidine (PCP) upon urine drug (UDS). It is believed that DXM also a positive opiates, presumably structural similarities. This could have serious implications, as reported be increasing. However, many these claims are anecdotal, no fully comprehensive studies exist. Furthermore, what been completed reveal does not despite their similarity in structure. Laboratories established cut-off limits opiates screen, and like all presumptive positives, confirmation with more sensitive methods strongly recommended rule out positives. * DXM : dextromethorphan PCP phencyclidine UDS screening DXO dextrorphan CNS central nervous system NMDA N-methyl-D-aspartate DAU abuse-urine EMIT enzyme multiplied immunoassay technique FPIA fluorescence polarization immunoassay RIA radioimmunoassay KIMS kinetic interaction microparticles solution CEDIA cloned donor SAMHSA Substance Abuse Mental Health Services Administration GC-MS gas chromatography-mass spectrometry LC-MS liquid HPLC high-performance chromatography