Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.

摘要: We investigated whether there is a relationship between the production of eicosanoids by murine solid tumors and their response to prostaglandin H (PGH) synthase inhibitor indomethacin. Three sarcomas, designated FSA, NFSA, SA-NH, two carcinomas, MCA-K HCA-I, syngeneic C3Hf/Kam mice were used. In general, FSA NFSA produced more PGH products than lipoxygenase products, whereas HCA-I both types metabolites in large quantities. All three responded well indomethacin treatment slowing growth. contrast, SA-NH insignificant quantities but substantial amounts products. Their growth was not affected with Indomethacin did influence tumor cell survival either vitro or vivo, it reduced proportion S-phase cells tumors. The antitumor effect immunosuppression host independent immunogenicity, implying that acted through nonimmunological mechanisms. Thus, effectiveness directly related ability produce PGs. Consequently, eicosanoid profile could serve as valuable way select patients likely respond other inhibiting agents.