Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma
作者： William W. Busse , Rohit Katial , David Gossage , Suha Sari , Bing Wang
DOI: 10.1016/J.JACI.2010.04.005
关键词: C-reactive protein 、 White blood cell 、 Eosinophil 、 Eosinophil cationic protein 、 Pharmacodynamics 、 Immunology 、 Pharmacokinetics 、 Medicine 、 Pharmacology 、 Eosinophil differentiation 、 Eosinopenia
摘要: … Immunohistochemistry studies of lung biopsies from subjects with mild asthma indicate that MEDI-563 stains more than 90% of eosinophils in the airways, suggesting that receptors for IL…
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