Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation
作者： Costantino Iadecola , Dale A. Pelligrino , Michael A. Moskowitz , Niels A. Lassen
关键词: Hypoxia (medical) 、 Cerebral blood flow 、 Cerebral circulation 、 Nitric oxide 、 Neuroscience 、 Vasodilation 、 Oxyde nitrique 、 Nitric oxide synthase 、 Medicine 、 Animal model 、 Neurology 、 Clinical neurology 、 Cardiology and Cardiovascular Medicine
摘要: There is increasing evidence that nitric oxide (NO) is an important molecular messenger involved in a wide variety of biological processes. Recent data suggest that NO is also involved in the regulation of the cerebral circulation. Thus, NO participants in the maintenance of resting cerebrovascular tone and may play an important role in selected vasodilator responses of the cerebral circulation. Furthermore, evidence has been presented suggesting that NO participates in the mechanisms of cerebral ischemic damage. Despite the widespread attention that NO has captured in recent years and the large number of studies that have been published on the subject, there is considerable controversy regarding the role of this agent in cerebrovascular regulation and in ischemic damage. In this paper the results of investigations on NO and the cerebral circulation are reviewed and the evidence for and against a role of NO is critically examined.
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Eiharu Morikawa, Sami Rosenblatt, Michael A. Moskowitz, L-arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. British Journal of Pharmacology. ,vol. 107, pp. 905- 907 ,(1992) , 10.1111/J.1476-5381.1992.TB13382.X
Fangyi Zhang, James G. White, Costantino Iadecola, Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia Journal of Cerebral Blood Flow & Metabolism. ,vol. 14, pp. 217- 226 ,(1994) , 10.1038/JCBFM.1994.28
T. Adachi, O. Inanami, A. Sato, Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats Neuroscience Letters. ,vol. 139, pp. 201- 204 ,(1992) , 10.1016/0304-3940(92)90552-I
Mieko Kurosawa, Akio Sato, Yuko Sato, Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats. Neuroscience Letters. ,vol. 98, pp. 45- 50 ,(1989) , 10.1016/0304-3940(89)90371-6
D. S. DeWitt, D. S. Prough, D. M. Colonna, D. D. Deal, S. M. Vines, NITRIC OXIDE SYNTHASE INHIBITORS DECREASE CEREBRAL BLOOD FLOW BUT DO NOT AFFECT PRESSURE AUTOREGULATION IN RATS Journal of Neurosurgical Anesthesiology. ,vol. 4, pp. 303- ,(1992) , 10.1097/00008506-199210000-00025
Shinya Sato, Teiji Tominaga, Tomoko Ohnishi, S.Tsuyoshi Ohnishi, EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat. Biochimica et Biophysica Acta. ,vol. 1181, pp. 195- 197 ,(1993) , 10.1016/0925-4439(93)90111-D
J W Kuluz, R J Prado, W D Dietrich, C L Schleien, B D Watson, The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats. Stroke. ,vol. 24, pp. 2023- 2029 ,(1993) , 10.1161/01.STR.24.12.2023
Frank M. Faraci, Regulation of the cerebral circulation by endothelium Pharmacology & Therapeutics. ,vol. 56, pp. 1- 22 ,(1992) , 10.1016/0163-7258(92)90035-X
T. Malinski, F. Bailey, Z. G. Zhang, M. Chopp, Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion Journal of Cerebral Blood Flow and Metabolism. ,vol. 13, pp. 355- 358 ,(1993) , 10.1038/JCBFM.1993.48
José Regidor, Lars Edvinsson, Ivan Divac, NOS neurones lie near branchings of cortical arteriolae. Neuroreport. ,vol. 4, pp. 112- 114 ,(1993) , 10.1097/00001756-199301000-00030