Poliovirus-induced changes in cellular membranes throughout infection

摘要: The membrane landscape of a cell often changes drastically upon infection by virus. In the case well-studied positive strand RNA virus poliovirus, short cycle induces vesicles and tubular structures early in infection, double-membraned late infection. this review, current understanding PV-infected cell, host viral factors that facilitate these changes, how may promote replication will be discussed. Host involved rearrangement during include components COPI COPII secretory pathways, lipid kinases, autophagy pathway. roles cellular membranes acting as scaffold for complex exit mature Finally, recent studies suggesting not all picornaviruses are truly ‘non-enveloped’ discussed context field, raising possibility cell-derived play role delivering poliovirus particles to extracellular space.