Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination.
作者： N. Dhiman , I. G. Ovsyannikova , N. A. Pinsky , R. A. Vierkant , S. J. Jacobsen
DOI: 10.1046/J.1365-2370.2003.00382.X
关键词: Biology 、 Measles 、 Measles vaccine 、 Human leukocyte antigen 、 Vaccination 、 TAP2 、 Immunoglobulin G 、 Immunology 、 Virology 、 Antibody 、 TAP1
摘要: The transporter associated with antigen processing (TAP) and human leukocyte antigen-DM (HLA-DM) genes are involved in the antigen-processing pathway of both HLA class I II-restricted presentation. We hypothesized that polymorphisms within TAP DM may influence antibody levels following measles vaccination. examined 242 school children from Olmsted County, Minnesota, USA who received one dose measles-mumps-rubella-II (MMR-II) vaccine at age 15 months. Based on level serum measles-specific immunoglobulin G (IgG) antibodies, subjects were classified as seronegatives (n = 72) or seropositives 170). determined TAP1 TAP2 allele types by polymerase chain reaction (PCR) amplification specific alleles (PASA) type PCR followed direct sequencing polymorphic sites. analysed data for any allelic association post vaccination using chi-square test univariate linear regression analysis. found no trend overall distribution genotype frequencies between seronegative seropositive subjects, suggesting polymorphism not directly associated. In addition, we did find an (TAP1, P 0.71; TAP2, 0.87) (DMA, 0.42; DMB, 0.71) homozygosity seronegativity to this study group. Our suggests gene do
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