Chapter 5 – The Neuropathogenesis of HIV-1 Infection

摘要: This chapter reviews the epidemiology, clinical manifestations, and pathology of HIV-1-associated neurological disease its associated encephalitis. Particular emphasis is placed on diagnosis, pathogenesis, treatment options now available or under investigation. demonstrates how HIV-1 infection brain results in neuronal injury death. Besides significant morbidity induced by for cognitive, motor, behavioral function, CNS represents an important reservoir continuous virus production emergence viral strain variance. Moreover, mechanisms mononuclear phagocytes (MP) secretory products may damage neurons have potential wide applicability other neurodegenerative disorders where inflammation component pathogenesis. Adjunctive therapies such as N-methyl D-aspartate receptor (NMDAR) blockers, chemokine cytokine effectors, antioxidants, caspase inhibitors, p38MAPK inhibitors are all interventions being developed many laboratories. If successful, these drugs find utility a broad range neurodestructive processes.