A revisit to the one form kinetic model of prothrombinase
作者： Chang Jun Lee , Sangwook Wu , Changsun Eun , Lee G. Pedersen
DOI: 10.1016/J.BPC.2010.03.011
关键词: Chemistry 、 Enzyme kinetics 、 Kinetic model 、 Kinetics 、 Crystallography 、 Prothrombinase 、 Thrombin 、 Biophysics 、 Molecular dynamics 、 One-form 、 Thromboplastin 、 Organic chemistry 、 Biochemistry
摘要: Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles independent groups for these have been re-analyzed. By rationally combining data sets, a simple mechanism can be established rate constants determined. A structural model consistent data-derived finding that mechanisms feature channeling or ratcheting are not necessary to describe thrombin production.
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