PAF-Binding and Endothelins Activity

摘要: Principle and Rationale Injection of platelet-activating factor (PAF) induces a wide range potent specific effects on target cells, including aggregation platelets shock symptoms like systemic hypotension, pulmonary hypertension, increased vascular permeability, neutropenia, thrombocytopenia. Inhalation PAF causes immediate bronchoconstriction followed by inflammation the airways (for further information, see section “Effect Arachidonic Acid or Respiratory Function In Vivo,” chapter “▶Respiratory Activity”). Hikiji et al. (2004) showed in PAF-deficient mice that absence receptor protects from osteoporosis following ovariectomy, model postmenopausal osteoporosis. is also implicated estrogen-induced angiogenesis via nuclear factor-kB activation (Seo 2004) delaying corneal wound healing (Bazan 2005). The belongs to superfamily G protein-coupled receptors (Chao Olson 1993; Izumi Shimizu 1995). Cloning studies have indicated single human gene containing an intron at 50 flanking region, providing alternative sequences (Ishii 2000). antagonists been reviewed extensively Koltai (1994) Summers Albert (1995). procedure used detect compounds inhibit binding H-PAF (plateletactivating factor) rabbit (PAF receptor).