Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C
作者： M Colonna , E. Brooks , M Falco , G. Ferrara , J. Strominger
关键词: Interleukin 12 、 Biology 、 Natural killer cell 、 Human leukocyte antigen 、 Major histocompatibility complex 、 Immunology 、 Lymphokine-activated killer cell 、 Interleukin 21 、 KIR Ligand 、 Molecular biology 、 Hybrid Resistance
摘要: The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex leukocyte antigen (HLA)-C molecules on surface target cell. Alloreactive NK specific for NK-1 alloantigen could be reproducibly generated from individuals that were homozygous HLA-C with asparagine at residue 77 and lysine 80 [HLA-C(Asn77,Lys80)] stimulation HLA-C(Ser77,Asn80); reciprocal yielded NK-2 alloantigen. However, neither cell stimulated generation alloreactive heterozygous individuals. Thus, these data reveal an unanticipated difference between alloreactivity defined this system murine "hybrid resistance."
sciencemag.org
unirioja.es
harvard.edu
elsevier.com参考文章(21)
R G Miller, S R Sambhara, Y Sasakura, B S Chadwick, Effect of class I MHC binding peptides on recognition by natural killer cells. Journal of Immunology. ,vol. 149, pp. 3150- 3156 ,(1992)
N M Wilkinson, K Saito, E Kubota, H Ishikawa, Modulation of F1 cytotoxic potentials by GvHR: suppression of cytotoxic T cell responses of F1 mice correlates with F1 inability to resist the proliferation of GvHR-inducing parental T lymphocytes. Journal of Immunology. ,vol. 129, pp. 1181- 1188 ,(1982)
L. L. Lanier, M. R. Loken, An My Le, J. H. Phillips, C. I. Civin, The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes Journal of Immunology. ,vol. 136, pp. 4480- 4486 ,(1986)
R D Salter, W J Storkus, P Cresswell, J R Dawson, Peptide-induced modulation of target cell sensitivity to natural killing. Journal of Immunology. ,vol. 149, pp. 1185- 1190 ,(1992)
R G Miller, B S Chadwick, Hybrid resistance in vitro. Possible role of both class I MHC and self peptides in determining the level of target cell sensitivity. Journal of Immunology. ,vol. 148, pp. 2307- 2313 ,(1992)
J Zemmour, P Parham, Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C. Journal of Experimental Medicine. ,vol. 176, pp. 937- 950 ,(1992) , 10.1084/JEM.176.4.937
T Hercend, J D Griffin, A Bensussan, R E Schmidt, M A Edson, A Brennan, C Murray, J F Daley, S F Schlossman, J Ritz, Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. Journal of Clinical Investigation. ,vol. 75, pp. 932- 943 ,(1985) , 10.1172/JCI111794
Hans-Gustaf Ljunggren, Klas Kärre, In search of the ‘missing self’: MHC molecules and NK cell recognition Immunology Today. ,vol. 11, pp. 237- 244 ,(1990) , 10.1016/0167-5699(90)90097-S
Christian Knobloch, Guntherw Dennert, Loss of F1 hybrid resistance to bone marrow grafts after injection of parental lymphocytes. Demonstration of parental anti-F1 T killer cells and general immunosuppression in the host. Transplantation. ,vol. 45, pp. 175- 183 ,(1988) , 10.1097/00007890-198801000-00037
Ermanno Ciccone, Marco Colonna, Oriane Viale, Daniela Pende, Carolina Di Donato, Daniel Reinharz, Antonio Amoroso, Michel Jeannet, John Guardiola, Alessandro Moretta, Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9794- 9797 ,(1990) , 10.1073/PNAS.87.24.9794