Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.
作者： E Perez-Reyes , A Castellano , H S Kim , P Bertrand , E Baggstrom
DOI: 10.1016/S0021-9258(18)46015-2
关键词: SCN3A 、 L-type calcium channel 、 Endocrinology 、 R-type calcium channel 、 Interleukin 10 receptor, alpha subunit 、 Internal medicine 、 Cell biology 、 Interleukin 5 receptor alpha subunit 、 Alpha (ethology) 、 Dihydropyridine 、 G alpha subunit 、 Biology
摘要: The skeletal muscle dihydropyridine receptor/Ca2+ channel is composed of five protein components (alpha 1, alpha 2 delta, beta, and gamma). Only two such components, 1 2, have been identified in heart. present study reports the cloning expression a novel beta gene that expressed heart, lung, brain. Coexpression this with cardiac Xenopus oocytes causes following changes Ca2+ activity: it increases peak currents, accelerates activation kinetics, shifts current-voltage relationship toward more hyperpolarized potentials. It also binding to COS cells. These results indicate L-type has similar subunit structure as muscle, provides evidence for modulatory role subunit.
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