A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer’ disease
作者： Pingping He , Xinping Ouyang , Shouhong Zhou , Weidong Yin , Chaoke Tang
DOI: 10.1016/J.YHBEH.2013.04.009
关键词: Alzheimer's disease 、 Receptor 、 Hippocampal formation 、 Piromelatine 、 Serotonin 、 Neuroprotection 、 Neuroscience 、 Agonist 、 Psychology 、 Melatonin
摘要: Previous studies have shown that melatonin is implicated in modulating learning and memory processing. Melatonin also exerts neuroprotective activities against Aβ-induced injury vitro vivo. Neu-P11 (piromelatine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide) a novel (MT1/MT2) receptor agonist serotonin 5-HT1A/1D recently developed for the treatment of insomnia. In present study we firstly investigated whether enhance performance object recognition (NOR) task rats, then assessed improve neuronal cognitive impairment rat model Alzheimer' disease (AD) induced by intrahippocampal Aβ(1-42) injection. The results showed single morning or afternoon administration enhanced measured at 4 24h after training. was effective facilitating effects only when administered afternoon. Further injection resulted hippocampal cellular loss, as well decreased ability Y maze NOR tasks rats. but not attenuated loss AD model. current data suggest may serve agent AD.
sci-hub.se 参考文章(54)
Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi, Susanna Rosi, Giancarlo Pepeu, Fiorella Casamenti, Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway Neurobiology of Disease. ,vol. 11, pp. 257- 274 ,(2002) , 10.1006/NBDI.2002.0538
Lenka Munoz, Hantamalala Ranaivo, Saktimayee M Roy, Wenhui Hu, Jeffrey M Craft, Laurie K McNamara, Laura Chico, Linda J Van Eldik, D Martin Watterson, A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model Journal of Neuroinflammation. ,vol. 4, pp. 21- 21 ,(2007) , 10.1186/1742-2094-4-21
James McLarnon, Jae Ryu, Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain. Current Alzheimer Research. ,vol. 5, pp. 475- 480 ,(2008) , 10.2174/156720508785908874
Jin Hyeong Jhoo, Hyoung-Chun Kim, Toshitaka Nabeshima, Kiyofumi Yamada, Eun-Joo Shin, Wang-Kee Jhoo, Wookyung Kim, Kee-Seok Kang, Sangmee Ahn Jo, Jong Inn Woo, β-Amyloid (1–42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex Behavioural Brain Research. ,vol. 155, pp. 185- 196 ,(2004) , 10.1016/J.BBR.2004.04.012
Rachael M. Clarke, Florence O'Connell, Anthony Lyons, Marina A. Lynch, The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β1–42 in the rat hippocampus in vivo Neuropharmacology. ,vol. 52, pp. 136- 145 ,(2007) , 10.1016/J.NEUROPHARM.2006.07.031
Carlos Spuch, Desiree Antequera, M. Isabel Fernandez-Bachiller, M. Isabel Rodríguez-Franco, Eva Carro, A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease Neurotoxicity Research. ,vol. 17, pp. 421- 431 ,(2010) , 10.1007/S12640-009-9121-2
Kiyofumi Yamada, Tomoko Tanaka, Daiken Han, Kouji Senzaki, Tsutomu Kameyama, Toshitaka Nabeshima, Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. European Journal of Neuroscience. ,vol. 11, pp. 83- 90 ,(1999) , 10.1046/J.1460-9568.1999.00408.X
N. J. Broadbent, L. R. Squire, R. E. Clark, Spatial memory, recognition memory, and the hippocampus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 14515- 14520 ,(2004) , 10.1073/PNAS.0406344101
Shi Du Yan, Xi Chen, Jin Fu, Ming Chen, Huaijie Zhu, Alex Roher, Timothy Slattery, Lei Zhao, Mariko Nagashima, John Morser, Antonio Migheli, Peter Nawroth, David Stern, Ann Marie Schmidt, RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease Nature. ,vol. 382, pp. 685- 691 ,(1996) , 10.1038/382685A0
William R. Markesbery, Oxidative Stress Hypothesis in Alzheimer's Disease Free Radical Biology and Medicine. ,vol. 23, pp. 134- 147 ,(1997) , 10.1016/S0891-5849(96)00629-6