Role of antibiotics and probiotics in the management of inflammatory bowel disease

摘要: An infectious cause or contribution to the primary pathogenesis of inflammatory bowel disease (IBD) has not been demonstrated, ahhough many studies have followed that track [1]. However, deleterious role some microorganisms from endogenous flora is also now well estabhshed in majority models colitis enteritis [1-4]. Antibiotics a weU-estabHshed management complications IBD such as abscess and pouchitis. Whether antibiotics are use therapy for either Crohn's (CD) ulcerative (UC) less clear. alternative way influencing intestinal ecology probiotics prebiotics. Probiotics defined living non-pathogenic which, when ingested, exert positive influence on host health physiology [5, 6]. Prebiotics non-digestible food ingredient beneficially affects by selectively stimulating growth and/or activity one limited number bacteria colon, potential improve [7]. As animal shown prebiotics may help preventing curing experimental colitis, clinical trials begun IBD. This chapter focuses metronidazole ciprofloxacin CD In addition, existing data other antimicrobial agents reviewed.