Proteomic analysis reveals geographic variation in venom composition of Russell's Viper in the Indian subcontinent: implications for clinical manifestations post-envenomation and antivenom treatment.
作者： Bhargab Kalita , Stephen P. Mackessy , Ashis K. Mukherjee
DOI: 10.1080/14789450.2018.1528150
关键词: Indian subcontinent 、 Biology 、 Envenomation 、 Russell's Viper 、 Antivenom 、 Immunology 、 Venom 、 VIPeR 、 Geographic variation
摘要: INTRODUCTION The Russell's Viper (RV) (Daboia russelii), a category I medically important snake, is responsible for significant level of morbidity and mortality in the Indian sub-continent. Areas covered: current review highlights variation RV venom (RVV) composition from different geographical locales on sub-continent, as revealed by biochemical proteomic analyses. A comparison these RVV proteomes differences number toxin isoforms relative abundances, highlighting impact geographic location composition. Antivenom efficacy studies have shown differential neutralization toxicity enzymatic activity samples sub-continent commercial polyvalent antivenom (PAV). proteome analysis has provided deeper insights into leading to severity clinical manifestations post RV-envenomation across Expert commentary: Variation antigenicity due poor recognition low molecular mass (<20 kDa) toxins PAV are serious concerns effective treatment against envenomation. Improvements immunization protocols that take account poorly immunogenic components composition, can lead better hospital management bite patients.
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