Prestin as a biochemical marker for early detection of acquired sensorineural hearing loss.

摘要: Acquired sensorineural hearing loss and tinnitus can come about through various etiologies such as exposure to excessively loud noise or drugs with ototoxic properties. As such, acquired is a common source of morbidity which deleteriously affects the ability communicate. At present our detect at its earliest stages limited there are no adjuncts audiometric evaluation. The cellular targets ototoxins in cochlea outer hair cells (OHC). I hypothesize that serum assays OHC specific protein, prestin, will allow detection quantification damage before testing identify presence loss. present, data available evaluate this hypothesis, but initial evaluation readily be carried out using existing experimental animal models ototoxicity noise-induced Early critical adoption measures aimed ameliorating tinnitus, thus reducing permanent deficits disability.